2. Signaling Pathways
  3. Neuronal Signaling
  4. Monoamine Oxidase

Monoamine Oxidase

MAO

Monoamine Oxidase

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Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase Isoform Specific Products:

Monoamine Oxidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131624
    LON 954
    		Inhibitor
    LON 954, a tremorogenic agent, is a reversible monoamine oxidase (MAO) inhibitor. LON 954 inhibits MAO activity in various tissue preparations.
    LON 954
  • HY-W335927
    MAO-B-IN-19
    		Inhibitor
    MAO-B-IN-19 is a selective MAO-B inhibitor with an IC50 of 0.67 μM. MAO-B-IN-19 shows neuroprotective and anti-inflammatory properties.
    MAO-B-IN-19
  • HY-148159
    Safrazine
    		Inhibitor
    Safrazine is an irreversible, non-specific and orally active monoamine oxidase (MAO) inhibitor. Safrazine can be used for the research of depression.
    Safrazine
  • HY-160002
    MAO-B-IN-27
    		Inhibitor
    MAO-B-IN-27 (Compound 12c) is a monoamine oxidase B (MAO-B) inhibitor. MAO-B-IN-27 has potent and selective MAO-B inhibitory effect for hMAO-B with an IC50 values of 8.9 nM. MAO-B-IN-27 can be used for the research of parkinson's disease (PD).
    MAO-B-IN-27
  • HY-174834
    MAO-B-IN-44
    		Inhibitor
    MAO-B-IN-44 (Compound 4n) is a selective monoamine oxidase B (MAO-B) inhibitor targetin with an IC50 value of 1.01 μM, showing weak inhibition on MAO-A (IC50=14.4 μM). MAO-B-IN-44 reduces degradation of neurotransmitters like dopamine. MAO-B-IN-44 is promising for research of neurodegenerative diseases related to MAO-B abnormalities such as Parkinson’s disease.
    MAO-B-IN-44
  • HY-157517
    MAO-B-IN-29
    		Inhibitor
    MAO-B-IN-29 (compound 9a) is a inhibitor against MAO-B activity.
    MAO-B-IN-29
  • HY-W083062
    hMAO-B-IN-5
    		Inhibitor 99.66%
    hMAO-B-IN-5 (Compound B15) is a potent, selective and reversible human monoamine oxidase-B (hMAO-B) inhibitor with an IC50 of 120 nM and a Ki of 33 nM. hMAO-B-IN-5 can be used in the research of neurodegenerative diseases.
    hMAO-B-IN-5
  • HY-151209
    MAO-B-IN-15
    		Inhibitor
    MAO-B-IN-15 is a selective MAO-B inhibitor (IC50: 13.5 μM) that forms π-π interaction with Tyr 326 residue. MAO-B-IN-15 can be used in the research of Parkinson’s disease.
    MAO-B-IN-15
  • HY-108048A
    Desoxypeganine hydrochloride
    		Inhibitor
    Desoxypeganine (Deoxypeganine) hydrochloride, an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine hydrochloride can be used for alcohol abuse research.
    Desoxypeganine hydrochloride
  • HY-17447AS
    (1S,2R)-Tranylcypromine-d5 hydrochloride
    (1S,2R)-Tranylcypromine-d5 (hydrochloride) is the deuterium labeled Tranylcypromine hydrochloride. Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression.
    (1S,2R)-Tranylcypromine-d<sub>5</sub> hydrochloride
  • HY-157087
    AChE/MAO-B-IN-4
    		Inhibitor
    AChE/MAO-B-IN-4 (compound 4a) is a selective dual AChE and MAO-B inhibitor. AChE/MAO-B-IN-4 shows no significant inhibition activity against BChE and h-MAO-A. AChE/MAO-B-IN-4 can be used for the Alzheimer’s disease (AD) research.
    AChE/MAO-B-IN-4
  • HY-N0505R
    Rosiridin (Standard)
    		Inhibitor
    Rosiridin (Standard) is the analytical standard of Rosiridin. This product is intended for research and analytical applications. Rosiridin inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC50=5.38).
    Rosiridin (Standard)
  • HY-181110
    MAO-A-IN-4
    		Inhibitor
    MAO-A-IN-4 is a highly selective and reversible inhibitor of monoamine oxidase A (MAO-A), with an IC50 of 0.06 μM against hMAO-A. MAO-A-IN-4 exhibits anti-inflammatory, antioxidant, neuroprotective, and antidepressant activities. MAO-A-IN-4 possesses favorable ADME properties and is suitable for research related to depression.
    MAO-A-IN-4
  • HY-156079
    Antidepressant agent 5
    Antidepressant agent 5 (Compound 3i) is a 7-substituted tetrahydroisoquinolines derivatives. Antidepressant agent 5 exhibits almost equal antidepressant activity compared with magnoflorine. ntidepressant agent 5 can be used for depressive disorder research.
    Antidepressant agent 5
  • HY-D3191
    L&M-D-MR
    		Substrate
    L&M-D-MR is a highly specific fluorescent "AND" logic probe with response moieties for leucine aminopeptidase (LAP) and monoamine oxidase (MAO). The coexistence of both LAP and MAO is required for L&M-D-MR to trigger intramolecular cyclization, release fluorophores and activate fluorescence. In the presence of only a single enzyme, L&M-D-MR generates only an extremely weak signal. L&M-D-MR enables bioimaging in living cells and mouse models, and can effectively distinguish different subtypes of liver diseases via blood samples or test strips. L&M-D-MR is widely used in studies related to liver cirrhosis, hepatitis B and drug-induced liver injury.
    L&M-D-MR
  • HY-151800
    MAO-A/B-IN-2
    		Inhibitor
    MAO-A/B-IN-2 (compound 30) is a MAO-A/B inhibitor with IC50 values of 17.8 and 15.8 μM for MAO-A and MAO-B, respectively. MAO-A/B-IN-2 can be used in the study of neurological disorders.
    MAO-A/B-IN-2
  • HY-148158
    Pivalylbenzhydrazine
    		Inhibitor
    Pivalylbenzhydrazine (Pivhydrazine) is a potent monoamine oxidase (MAO) inhibitor. Pivalylbenzhydrazine decreases cartilage growth in normal rats. Pivalylbenzhydrazine can be used in research of depression.
    Pivalylbenzhydrazine
  • HY-181141
    AChE/MAO-B-IN-8
    		Inhibitor
    AChE/MAO-B-IN-8 is an acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B) inhibitor with IC50 values of 0.72 and 0.19 μM. AChE/MAO-B-IN-8 interactions with AChE and MAO-B active-site amino acid residues. AChE/MAO-B-IN-8 can be used for the research of Alzheimer’s disease.
    AChE/MAO-B-IN-8
  • HY-143245
    Monoamine Oxidase B inhibitor 2
    		Inhibitor
    Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active and selective monoamine oxidase B (MAO-B) inhibitor with an IC50 of 1.33 nM. Monoamine Oxidase B inhibitor 2 has antioxidant and anti-neuroinflammatory activities. Monoamine Oxidase B inhibitor 2 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study.
    Monoamine Oxidase B inhibitor 2
  • HY-W083026
    (E)-CHBO4
    		Inhibitor
    (E)-CHBO4 is a MAO-B inhibitor, with an IC50 of 0.023 μM, and can be used for research on the study of Parkinson's disease.
    (E)-CHBO4
Cat. No. Product Name / Synonyms Application Reactivity
Monoamine Oxidase Isoform Comparison

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